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Herbs & Supplements

2-Amino-2-Deoxyglucose
Scientific Name: Glucosamine
Other Names: Chitosamine, Glucosamine Hydrochloride, Glucosamine Sulfate, N-acetyl Glucosamine

References

Anon: Glucosamine. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. September 2002.

Bailey CJ, Turner SL. Glucosamine-induced insulin resistance in L6 muscle cells. Diabetes, Obesity and Metabolism. 2004;6(4):293-298.

Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes. 1994;43(10):1173-1179.

Barclay TS, Tsourounis C, McCart GM. Glucosamine. Annals of Pharmacotherapy. 1998;32(5):574-579.

Barrett S. Glucosamine for arthritis. January 23, 2002. QuackWatch. Available at: http://www.quackwatch.org/01QuackeryRelatedTopics/DSH/glucosamine.html. Accessed September 27, 2004.

Biggee BA, Blinn CM, Nuite M, Silbert JE, McAlindon TE. Effects of oral glucoamine [sic] sulphate [sic] on serum glucose and insulin during an oral glucose tolerance test of subjects with osteoarthritis. Annals of Rheumatic Diseases. Epublished ahead of print July 3, 2006.

Blaurock-Busch E. The clinical effects of manganese (Mn). Townsend Letter for Doctors and Patients. No date given. Available at: http://www.tldp.com/issue/180/Clinical%20Effects%20of%20Mn.html. Accessed September 23, 2003.

Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 2003;37(1):45-49.

Bruyere O, Pavelka K, Rovati LC, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause. 2004;11(2):138-143.

Bruyere O, Reginster JY. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs and Aging. 2007;24(7):573-580.

Chen JT, Liang JB, Chou CL, et al. Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro. Investigative Ophthalmology and Visual Science. 2006;47(2):664-672.

Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair and Regeneration. 1999;7(2):79-89.

Christgau S, Henrotin Y, Tanko LB, et al. Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate [sic]. Clinical and Experimental Rheumatology. 2004;22(1):36-42.

Chu SC, Yang SF, Lue KH, et al. Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clinica Chimica Acta. Epublished ahead of print June 4, 2006.

Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. 2006;354(8):795-808.

Cole DJ, Connolly RJ, Chan MW, et al. A pilot study evaluating the efficacy of a fully acetylated poly-N-acetyl glucosamine membrane formulation as a topical hemostatic agent. Surgery. 1999;126(3):510-517.

Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheumatic Disease Clinics of North America. 1999;25(2):379-395.

Duan W, Paka L, Pillarisetti S. Distinct effects of glucose and glucosamine on vascular endothelial and smooth muscle cells: evidence for a protective role for glucosamine in atherosclerosis. Cardiovascular Diabetology. 2005;4:16.

Forsyth RK, Brigden CV, Northrop AJ. Double blind investigation of the effects of oral supplementation of combined glucosamine hydrochloride (GHCL) and chondroitin sulphate [sic] (CS) on stride characteristics of veteran horses. Equine Veterinary Journal Supplement 2006;(36):622-625.

Fox BA, Schmitz ED, Wallace R. FPIN's clinical inquiries. Glucosamine and chondroitin for osteoarthritis. American Family Physician. 2006;73(7):1245-1246.

Fraenkel L, Bogardus ST Jr, Concato J, Wittink DR. Treatment options in knee osteoarthritis: the patient's perspective. Archives of Internal Medicine. 2004;164(12):1299-1304.

Frech TM, Clegg DO. The utility of nutraceuticals in the treatment of osteoarthritis. Current Rheumatology Reports. 2007;9(1):25-30.

Gatti JC. Glucosamine treatment for osteoarthritis. American Family Physician. 2006;73(7):1189-1191.

Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia. 1995;38(5):518-524.

Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs. 1994;47(3):536-566.

Han DH, Chen MM, Holloszy JO. Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle. American Journal of Physiology, Endocrinology and Metabolism. 2003;285(6):E1267-E1272.

Hathcock JN, Shao A. Risk assessment for glucosamine and chondroitin sulfate. Regulatory Toxicology and Pharmacology. 2007;47(1):78-83.

HealthNotes, Inc. Glucosamine. 2002. Available at: http://www.mycustompak.com/healthNotes/Supp/Glucosamine.htm Accessed September 23, 2003.

HealthNotes, Inc. Glucosamine/Chondroitin. 2002. Available at: http://www.mycustompak.com/healthNotes/Supp/Glucosamine_Chondroitin.htm. Accessed September 23, 2003.

Henderson CJ. Dietary Outcomes in Osteoarthritis Disease Management. Bulletin on the Rheumatic Diseases. 2003-2004;52(12): Available at: http://www.arthritis.org/research/bulletin/vol52no12/Printable.htm. Accessed September 27, 2004.

Herrero-Beaumont G, Rovati LC, Castaneda S, Alvarez-Soria MA, Largo R. The reverse glucosamine sulfate pathway: application in knee osteoarthritis. Expert Opinion in Pharmacotherapy. 2007;8(2):215-225.

Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes. 1999;48(1):106-111.

Homandberg GA, Guo D, Ray LM, Ding L. Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone. Osteoarthritis and Cartilage. 2006;14(8):793-806.

Hopman WM, Towheed TE, Gao Y, et al. Prevalence of and factors associated with glucosamine use in Canada. Osteoarthritis and Cartilage. Epublished ahead of print July 8, 2006.

Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. Journal of Rheumatology. 1999;26(11):2423-2430.

Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate [sic] as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford). 2002;41(3):279-284.

Hungerford DS, Jones LC. Glucosamine and chondroitin sulfate are effective in the management of osteoarthritis. Journal of Arthroplasty. 2003;18(3 Suppl 1):5-9.

Institute of Medicine. U.S. National Academy of Sciences. Dietary reference intakes for vitamin A, vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. www.nap.edu/books/0309072794/html. Accessed September 23, 2003.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Liao YH, Jones SA, Forbes B, Martin GP, Brown MB. Hyaluronan: pharmaceutical characterization and drug delivery. Drug Delivery. 2005;12(6):327-342.

Lippiello L, Woodward J, Karpman R, Hammad TA. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clinical Orthopedics. 2000;(381):229-240.

Lu-Suguro JF, Hua J, Sakamoto K, Nagaoka I. Inhibitory action of glucosamine on platelet activation in guinea pigs. Inflammation Research. 2005;54(12):493-499.

MacKay D, Miller AL. Nutritional support for wound healing. Alternative Medicine Review. 2003;8(4):359-377.

Matheson AJ, Perry CM. Glucosamine: a review of its use in the management of osteoarthritis. Drugs and Aging. 2003;20(14):1041-1060

McAlindon T. Glucosamine and chondroitin for rheumatoid arthritis? Bulletin on the Rheumatic Diseases. 2001;50(7):1-4.

McAlindon T. Why are clinical trials of glucosamine no longer uniformly positive? Rheumatic Disease Clinics of North America. 2003;29(4):789-801.

McAlindon TE. Nutraceuticals: do they work and when should we use them? Best Practice and Research. Clinical Rheumatology. 2006 ;20(1):99-115.

McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and Chondroitin for Treatment of Osteoarthritis. A Systematic Quality Assessment and Meta-analysis. Journal of the American Medical Association. 2000;283(11):1469-1475.

McCarty MF. Glucosamine for wound healing. Medical Hypotheses. 1996;47(4):273-275.

McCarty MF. Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis. Medical Hypotheses. 1998;50(6):507-510.

McCarty MF, Russell AL, Seed MP. Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesis. Medical Hypotheses. 2000;54(5):798-802.

McMillan DE. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology. 1999;20(2-3):499-507.

Miller DC, Richardson J. Does glucosamine relieve arthritis joint pain? Journal of Family Practice. 2003;52(8):645-647.

Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes. 2000;49:926-935.

Muller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and Cartilage. 1994;2(1):61-69.

Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes. 2006;55(11):3142-3150.

Murad H, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study. Journal of Dermatology Treatment. 2001;12(1):47-51.

National Center for Complementary and Alternative Medicine. National Institutes of Health. Backgrounder. Questions and answers: NIH Glucosamine/chondroitin Arthritis Intervention Trial (GAIT). Updated August 2007. Available at: http://nccam.nih.gov/research/results/gait/D310_BKG.PDF. Accessed September 21, 2007.

Natural Medicines Comprehensive Database, Online Edition. Pharmacist's Letter/Prescriber's Letter. Stockton CA: Therapeutic Research Facility, 2006. Available at: http://www.pharmacistsletter.com/(S(ulqz3s45omt3ag55um4kj345))/home.aspx?li=1&st=1&cs=&s=ND.

Nguyen P, Mohamed SE, Gardiner D, Salinas T. A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: a pilot study. Cranio. 2001 Apr;19(2):130-139.

Nowlan C, Wetmore S. Short report: ibuprofen versus glucosamine sulfate. Treating osteoarthritis pain. Canadian Family Physician. 2003;49:1632-1634.

Nowak A, Szczesniak L, Rychlewski T, Dylewicz P, Przywarska I. Glucosamine levels in people with ischaemic [sic] heart disease with and without type II diabetes. Pol Arch Med Wewn. 1998;100(5):419-425.

Olszewski AJ, Szostak WB, McCully KS. Plasma glucosamine and galactosamine in ischemic heart disease. Atherosclerosis. 1990;82(1-20:75-83.

Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-blind Study. Archives of Internal Medicine. 2002;162(18):2113-2123.

Persiani S, Roda E, Rovati LC, Locatelli M, Giacovelli G, Roda A. Glucosamine oral bioavailability and plasma pharmacokinetics after increasing doses of crystalline glucosamine sulfate in man. Osteoarthritis and Cartilage. 2005;13(12):1041-1049.

Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Annals of Pharmacotherapy. 2005;39(6):1080-1087.

Poustie MW, Carran J, McElerney K, Dixon SJ, Anastassiades TP, Bernier SM. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. July 7, 2004.

Priebe D, McDiarmid T, Mackler L, Tudiver F. Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis? Journal of Family Practice. 2003;52(3):237-239.

Prototype monograph on glucosamine. Institute of Medicine and National Research Council of the National Academies. 2004. Available at: http://www.iom.edu/Object.File/Master/19/560/Introduction%20and%20Glucosamine%20Prototype%20Monograph.v2.pdf. Accessed: September 7, 2007.

Qiu GX, Gao SN, Giacovelli G, Rovati L, Setnikar I. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998;48(5):469-474.

Qiu W, Avramoglu-Kohen R, Rutledge AC, Tsai J, Adeli K. Mechanisms of glucosamine-induced suppression of hepatic assembly and secretion of apolipoprotein B100-containing lipoproteins. Journal of Lipid Research. Epublished ahead of print May 3, 2006.

Reginster JY, Bruyere O, Lecart MP, Henrotin Y. Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis. Current Opinion in Rheumatology. 2003;15(5):651-655.

Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate [sic] on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251-256.

Reginster JY, Bruyere O, Neuprez A. Current role of glucosamine in the treatment of osteoarthritis. Rheumatology (Oxford). 2007;46(5):731-735.

Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 2003;163(13):1514-1522.

Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. American Journal of Health-System Pharmacists. 2004;61(3):306-307.

Russell AL. Glucosamine in osteoarthritis and gastrointestinal disorders: an exemplar of the need for a paradigm shift. Medical Hypotheses. 1998;51(4):347-349.

Sarzi-Puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Seminars in Arthritis and Rheumatism. 2005;35(1 Suppl 1):1-10.

Schwaitzberg SD, Chan MW, Cole DJ, et al. Comparison of poly-N-acetyl glucosamine with commercially available topical hemostats for achieving hemostasis in coagulopathic models of splenic hemorrhage. Journal of Trauma. 2004;57(1 Suppl):S29-S32.

Scott GN. Glucosamine-chondroitin interaction with warfarin. Pharmacist's Letter/Prescriber's Letter Detail Document #200305. March 2004.

Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Archives of Internal Medicine. 2003;163(13):1587-1590.

Setnikar I, Palumbo R, Canali S, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneimittelforschung 1993;43(10):1109-1113.

Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism. 1998;47(5):573-577.

Shankland WE 2nd. The effects of glucosamine and chondroitin sulfate on osteoarthritis of the TMJ: a preliminary report of 50 patients. Cranio. 1998;16(4):230-135.

Shaunak S, Thomas S, Gianasi E, et al. Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation. Nature Biotechnology. 2004;22(8):977-984.

Soeken KL. Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews. Clinical Journal of Pain. 2004;20(1):13-18.

Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Annals of Pharmacotherapy. 2006;40(4):694-698.

Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. Journal of the American Board of Family Practice. 2002;15(6):481-484.

Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis and Cartilage. 2004;12(6):506-511.

Tannock LR, Kirk EA, King VL, LeBoeuf R, Wight TN, Chait A. Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor-deficient mice. Journal of Nutrition. 2006;136(11):2856-2861.

Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. Journal of Rheumatology. 2001;28(6):1347-1355.

Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MC. Glucosamine therapy for treating osteoarthritis. Cochrane Database System Review. 2001;(1):CD002946.

Uitterlinden EJ, Jahr H, Koevoet JL, et al. Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis and Cartilage. 2006;14(3):250-257.

Varghese S, Theprungsirikul P, Sahani S, Hwang N, Yarema KJ, Elisseeff JH. Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. Osteoarthritis and Cartilage. 2007;15(1):59-68.

Villacis J, Rice TR, Bucci LR, et al. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine? Clinical and Experimental Allergy. 2006;36(11):1457-1461.

Vlad SC, LaValley MP, McAlindon TE, Felson DT. Glucosamine for pain in osteoarthritis: why do trial results differ? Arthritis and Rheumatism. 2007;56(7):2267-2277.

Vournakis JN, Demcheva M, Whitson AB, Finkielsztein S, Connolly RJ. The RDH bandage: hemostasis and survival in a lethal aortotomy hemorrhage model. Journal of Surgical Research. 2003;113(1):1-5.

Wallis MG, Smith ME, Kolka CM, et al. Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment. Diabetologia. 2005;48(10):2131-2139.

Wells L, Vosseller K, Hart GW. A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cellular and Molecular Life Sciences. 2003;60(2):222-228.

Werstuck GH, Khan MI, Femia G, et al. Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes. 2006;55(1):93-101.

Winslet MC, Poxon V, Allan A, Keighley MR. Mucosal glucosamine synthetase activity in inflammatory bowel disease. Digestive Disease Science. 1994;39(3):540-544.

Xing R, Liu S, Guo Z, et al. The antioxidant activity of glucosamine hydrochloride in vitro. Bioorganic Medicinal Chemistry. 2006;14(6):1706-1709.

Yang S, Zou LY, Bounelis P, Chaudry I, Chatham JC, Marchase RB. Glucosamine administration during resuscitation improves organ function after trauma hemorrhage. Shock. 2006;25(6):600-607.

Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncology Research. 1995;7(12):583-590.

Zerkak D, Dougados M. The use of glucosamine therapy in osteoarthritis. Current Rheumatology Reports. 2004;6(1):41-45.

Zhang GX, Yu S, Gran B, Rostami A. Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. Journal of Immunology. 2005;175(11):7202-7208.

Last Revised August 9, 2007

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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